macrocycle in English dictionary macrocycle Meanings and definitions of "macrocycle" (chemistry) a cyclic macromolecule, or a macrocyclic portion of a molecule noun (chemistry) a cyclic macromolecule, or a macrocyclic portion of a molecule noun In sports training, an annual plan that works towards peaking for the goal competition of the year. more Grammar and declension of macrocycle macrocycle ( plural macrocycles) more Sample sentences with "macrocycle" Declension Stem Try again Available translations French German Irish Tamil Authors