zileuton in English dictionary zileuton Meanings and definitions of "zileuton" An asthma drug that blocks leukotriene synthesis by inhibiting 5-lipoxygenase, an enzyme of the eicosanoid synthesis pathway. noun An asthma drug that blocks leukotriene synthesis by inhibiting 5-lipoxygenase, an enzyme of the eicosanoid synthesis pathway. more Grammar and declension of zileuton zileuton ( uncountable) zileuton (uncountable) more Zileuton Sample sentences with "zileuton" Declension Stem Try again Available translations Dutch French German Hebrew Italian Japanese Norwegian Nynorsk Serbian Serbo Croatian Spanish Welsh Authors