Translation of "and therefore" into Spanish

When their family responsibilities increased, they both commenced working part-time and therefore lost that status.

Cuando aumentaron sus responsabilidades familiares ambas comenzaron a trabajar a tiempo parcial y, por consiguiente, perdieron dicha categoría.

There are sentences whose translation into certain languages doesn't make sense and, therefore, should be avoided.

Hay frases cuya traducción a determinados idiomas no tiene sentido y, por lo tanto, se debe evitar.