Translation of "evo-devo-morfologia" into English

Carroll et.al (2005) emphasized the key roles in the DEVELOPMENT of transcription factor (TF:S) and signaling proteins that impact GENE EXPRESSION in embryo development. Genes that encode development and diffrentiation - were referred to as TOOLKIT GENES. These genes occurs as genefamilies like:SHH, WNT, NOTH, EGF, FGF and TOLL-like genenes (immune response) .These gene-families controls the EXPRESSIONS of other toolkit-genes - by producing signaling proteins for them, like to lately founded HOX-genes - which contains homeobox sequence (180-base pairs). These genes constructs body-longitudinal-axel with proteinsynthesises. When producing MORPHOLOGICAL DIVERSITY - those mentioned genefamilies, as SHH (sonic hedgehog) and Wnt (wingless), are acting between different genes and celltypes - influencing in fetal development to THAT: how, in what developmental phase, and how intensively participating genes or cells are expressed. They are "MASTER EXPRESSION SWITCHES", means - they can either shutt off - or activate the expressions of extant gene-complexes as ON/OFF states. They communicates, as developmental signaling pathways. Instead off - HOX-GENES belongs to HOMEOTIC genes - and their function - from the beginning - is to produce and maintain different CELL-TYPES- and CELL-IDENTITES, when they differentiates in these fetal development-phases. They are steered by GRN:s regulatoty factors - and called "MASTER REGULATORY GENES" in producing and uppkeeping different cell- and tissue types. In evo-devo morphology, the MAIN EFFECTOR which drives new MORPHOLOGIES - is so called CIS-state histone modification factor (with histone markers epimutations). This EPIGENETICAL process is called CIS-regulatory-elements (CRE:s). Cis-means, that these elements are LOCATED in the same DNA-strand, where chromatinloop brings Enchangers and protein copying Promoters to nearby LOCATIONS - these targetspecific positions can be DEVELOPING in producing NEW TRAITS in this "epigenetic landscape".