debuff in English dictionary debuff Meanings and definitions of "debuff" (gaming) An effect that makes a game character weaker; a status effect. noun (role-playing games, video games) An effect that makes a game character weaker; a negative status effect. verb (role-playing games, video games) To make a character or unit weaker. more Grammar and declension of debuff debuff ( plural debuffs) debuff (plural debuffs) debuff (third-person singular simple present debuffs, present participle debuffing, simple past and past participle debuffed) more Sample sentences with "debuff" Declension Stem Try again Available translations French Authors