pootie in English dictionary pootie Meanings and definitions of "pootie" (slang) A common nickname between lovers. (slang) A baby soother (vulgar, slang) The female genitalia; the vulva or vagina. noun (slang) A common nickname between lovers. noun (slang) A baby soother noun (vulgar, slang) The female genitalia; the vulva or vagina. more Grammar and declension of pootie pootie ( plural pooties) pootie (plural pooties) more Sample sentences with "pootie" Declension Stem Try again Authors